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David M Goldstein Selected Research

PRN1371

12/2017The Irreversible Covalent Fibroblast Growth Factor Receptor Inhibitor PRN1371 Exhibits Sustained Inhibition of FGFR after Drug Clearance.
10/2017Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.

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David M Goldstein Research Topics

Disease

5Rheumatoid Arthritis
01/2015 - 12/2008
4Neoplasms (Cancer)
12/2017 - 05/2012
4Autoimmune Diseases (Autoimmune Disease)
03/2014 - 10/2003
2Experimental Arthritis
01/2021 - 12/2008
2Arthus Reaction
01/2021 - 01/2021
2Asthma (Bronchial Asthma)
03/2014 - 12/2012
2Inflammation (Inflammations)
12/2008 - 10/2003
1Pemphigus (Pemphigus Vulgaris)
01/2021
1Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
01/2021
1Skin Diseases (Skin Disease)
01/2021
1Nephritis
01/2021
1Systemic Lupus Erythematosus (Libman-Sacks Disease)
12/2008
1Hyperalgesia
12/2008
1Pain (Aches)
12/2008

Drug/Important Bio-Agent (IBA)

3Agammaglobulinaemia Tyrosine KinaseIBA
01/2021 - 05/2012
2Pharmaceutical PreparationsIBA
12/2017 - 01/2015
2PRN1371IBA
12/2017 - 10/2017
2Syk KinaseIBA
03/2014 - 12/2012
2CytokinesIBA
12/2008 - 10/2003
1PRN473IBA
01/2021
1AutoantibodiesIBA
01/2021
1Immunoglobulin G (IgG)IBA
01/2021
1Phosphotransferases (Kinase)IBA
12/2017
1Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
12/2017
1RN486IBA
01/2015
1Cytochrome P-450 CYP3AIBA
06/2012
1Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
06/2012
1pamapimodIBA
12/2008
1Protein Kinases (Protein Kinase)IBA
12/2008
1Interleukin-1 (Interleukin 1)IBA
10/2003
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2003